29 de abr de 2015

Functional neurologic recovery in two dogs diagnosed with severe luxation of the vertebral column

Recuperação da função neurológica em dois cães com deslocamento grave da coluna vertebral

 Semina: Ciências Agrárias, Londrina, v. 36, n. 2, p. 901-908, mar./abr. 2015

Mônica Vicky Bahr Arias; Daniela Scapini Mendes; Nazilton de Paula Reis Filho

 Abstract: Traumatic injuries to the vertebral column, spinal cord, and cauda equina nerve roots occur frequently in human and veterinary medicine and lead to devastating consequences. Complications include partial or complete loss of motor, sensory, and visceral functions, which are among the main causes of euthanasia in dogs. The present case report describes neurological functional recovery in two dogs that were treated surgically for severe spinal fracture and vertebral luxation. In the first case, a stray, mixed breed puppy was diagnosed with thoracolumbar syndrome and Schiff-Scherrington posture, as well as a T13 caudal epiphyseal fracture with 100% luxation between vertebrae T13 and L1; despite these injuries, the animal did show deep pain sensation in the pelvic limbs. Decompression through hemilaminectomy and spinal stabilization with vertebral body pins and bone cement were performed, and the treatment was supplemented with physiotherapy and acupuncture . In the second case, a mixed breed dog was diagnosed with a vertebral fracture and severe luxation between L6 and L7 after a vehicular trauma, but maintained nociception and perineal reflex. Surgical stabilization of the spine was performed using a modified dorsal segmental fixation technique Both patients showed significant recovery of neurological function. Complete luxation of the spinal canal observed radiographically does not mean a poor prognosis, and in some cases, motor, sensory, and visceral functions all have the potential for recovery. In the first case the determining factor for good prognosis was the presence of deep pain perception, and in the second case the prognosis was determined by the presence of sensitivity and anal sphincter tone during the initial neurological examination.

Resumo: Lesões traumáticas à coluna vertebral, medula espinhal e raízes nervosas da cauda equina ocorrem frequentemente na medicina veterinária e humana, levando a sequelas devastadoras, como perda parcial ou completa das funções motoras, sensoriais e viscerais, sendo a ocorrência destas sequelas uma das principais causas de eutanásia em cães. O objetivo do presente trabalho é relatar a recuperação da função neurológica em dois cães com fratura vertebral e deslocamento do canal medular de mais de 100% tratados cirurgicamente. O primeiro caso ocorreu em um filhote de cão sem raça definida (SRD) encontrado na rua com síndrome toracolombar e presença de postura de Schiff-Scherrington, constatando-se fratura em epífise caudal do corpo vertebral de T13 com luxação grave entre as vértebras T13 e L1, porém o animal apresentava sensibilidade dolorosa profunda em membros pélvicos. O tratamento utilizado neste caso foi descompressão através de hemilaminectomia e estabilização da coluna com pinos nos corpos vertebrais e cimento ósseo, além de fisioterapia e acupuntura. O segundo caso ocorreu em cão SRD atropelado, que apresentou fratura e luxação entre L6, L7 e grande desvio entre os fragmentos, que porém apresentava nocicepção e reflexo perineal preservado. O tratamento realizado foi a estabilização da coluna através da técnica de fixação segmentar dorsal modificada. Ambos os pacientes apresentaram recuperação significativa da função neurológica, permanecendo com discreta paresia de membros posteriores. O deslocamento de 100% do canal vertebral à avaliação radiográfica não significa prognóstico ruim, havendo em alguns casos chance de recuperação das funções motoras, sensoriais e viscerais. No primeiro caso o fator determinante para o bom prognóstico foi a presença de percepção da dor profunda, e no segundo caso, o prognóstico foi determinado pela presença de sensibilidade e tônus no esfíncter anal durante o exame neurológico inicial.


13 de abr de 2015

Diagnóstico presuntivo de embolismo fibrocartilaginoso em 12 cães

Presumptive Diagnosis of Fibrocartilaginous Embolism in 12 Dogs
Acta Scientiae Veterinariae, 2013. 41(Suppl 1): 25

Rafael Oliveira Chaves, Diego Vilibaldo Beckmann, Rosmarini Passos dos Santos, Amanda Oliveira Andrades, Matheus Macagnan, Graciane Aiello, André Vasconcelos Soares & Alexandre Mazzanti

 Background: Fibrocartilaginous embolic myelopathy is a syndrome of spinal cord infarction caused by fi brocartilaginous emboli identical to the nucleus pulposus of intervertebral disk. The signals were acute and not progressive, asymmetric in 92% and neuroanatomic regions were affected C6-T2 (n = 2), L3-T3 (n = 5) and L4-S3 (n = 5). The diagnosis was based on history, fi ndings on physical and neurological examination and exclusion of differential diagnosis. The aim of this study was to report twelve dogs treated at Hospital Veterinário Universitário (HVU), Universidade Federal de Santa Maria (UFSM) with a presumptive diagnosis of fi brocartilaginous embolism. Cases: Seven males and fi ve females dogs were referred to the Veterinary Teaching Hospital of the Federal University of Santa Maria: three rottweiler dogs, two labradors retrievers, one fi la brasileiro, one chow-chow, one boxer, one schnauzer, one German shepherd, one mixed breed and one greyhound, aged between one year and three months and eleven. In all cases, the owners reported during the anamnesis partial or complete loss of movement of member(s) involved(s) acutely with no history of trauma. For anatomical localization of the lesion was performed neurological examination. As complementary exams were requested blood count, serum biochemistry, urinalysis, and radiography of the spine. Contrast radiography (myelography) and cerebrospinal fl uid analysis were performed only in eight dogs. Front of the historical, clinical fi ndings, neurological and complementary exams the presumptive diagnosis was fi brocartilaginous embolism. The dogs were subjected to passive physical therapy and showed satisfactory clinical improvement in the first month after onset of clinical signs. Discussion: The myelopathy fi brocartilaginous embolism is commonly reported in dogs of large and giant breed. In this study, 92% were of large breeds. The mean age of onset of clinical signs in this study was 4.5 years, and male dogs, the most affected, result similar to that found in other studies. Neurological signs vary depending on the location and severity of ischemic lesions of the spinal cord and asymmetric signals in 55% to 61% of the dogs. Of the twelve dogs of this study, signals were asymmetric and eleven of them were affected neuroanatomic regions C6-T2 (n = 2), L3-T3 (n = 5) L4-S3 (n = 5). In other studies, the most affected areas were T3-L3 and L4-S3. Intensive physical activity seems to be involved in about half the cases of embolism few hours. Except for two dogs of breed rottweiler and SRD in this study, all had a history of physical activity at the onset of clinical signs. There were no changes in blood count, serum biochemistry, urinalysis, and radiography of the spine in the twelve dogs. With the exception of four dogs, the other underwent contrast radiography (myelography) and cerebrospinal fl uid analysis and only in German Shepherd and Labrador was observed intramedullary compression standard to myelography and mild lymphocytic pleocytosis and increased protein in the CSF, respectively. Diagnosis of fi brocartilaginous embolism cases in this study was based on history, fi ndings on physical and neurological examination, exclusion of differential diagnosis by laboratory tests and clinical evolution. In ten dogs of this study, was performed only physical therapy and nine of them were observed clinical signs of recovery between one and fi ve weeks. The study brings to clinical relevance, the importance of fi brocartilaginous embolism in the differential diagnosis of dogs with a history of acute loss of limb movements, with or without asymmetry, non-progressive, no pain on palpation of the spine. This may be favorable prognosis in patients with signs of recovery during the first month.

8 de abr de 2015

Prednisona e meloxicam no tratamento de ratos submetidos ao trauma agudo da medula espinhal

Prednisone and meloxicam in the treatment of rats underwent to acute spinal cord injury

 Graciane Aiello, Alexandre Mazzanti, Diego Vilibaldo Beckmann, Rosmarini Passos dos Santos, Amanda Oliveira de Andrades,Heloisa Einloft Palma, Cinthia Melazzo de Andrade, André Vasconcelos Soares

 Ciência Rural, Santa Maria, v.45, n.1, p.124-130, jan, 2015


RESUMO O objetivo deste estudo foi investigar o efeito da prednisona e do meloxicam na terapia de ratos submetidos ao modelo experimental de trauma agudo da medula espinhal, induzida pelo cateter de Fogarty 2Fr, mediante a avaliação dos parâmetros de estresse oxidativo, dos testes neurológicos e do exame histopatológico da medula espinhal. Foram utilizados 90 ratos Wistar, distribuídos em seis grupos, denominados controle salina ou GCS (n=15), controle prednisona ou GCP (n=15), controle meloxicam ou GCM (n=15), trauma mais salina ou GTS (n=15), trauma mais prednisona ou GTP (n=15) e trauma mais meloxicam GTM (n=15). Cada grupo foi redistribuído em três subgrupos de igual número, de acordo com o tempo de tratamento no pós-operatório de 24h, 72h e sete dias. Todos os grupos foram submetidos à laminectomia e, nos grupos GTS, GTM e GTP, após a exposição da medula espinhal, foi realizado o trauma medular compressivo, utilizando o cateter de Fogarty 2Fr. Os grupos GCS e GTS foram tratados com solução salina, os GSM e GTM receberam meloxicam e os GSP e GTP prednisona, sendo administrados pela via intraperitoneal. Em todos os ratos, foram avaliados os parâmetros de estresse oxidativo, testes neurológicos e exame histopatológico da medula espinhal. Os animais dos grupos GTS, GTM e GTP, nos diferentes tempos (24h, 72h e sete dias), tiveram pontuação zero na escala de Basso, Beattie e Bresnahan (BBB); no plano inclinado, permaneceram com pontuação três e perderam a percepção da dor profunda. Os grupos GTM e GTP apresentaram menor atividade da catalase e de níveis de TBARS, quando comparado ao grupo GTS. Foi constatada degeneração Walleriana e necrose da substância cinzenta de intensidades variáveis, não apresentando diferença entre os grupossubmetidos ao trauma. O meloxicam e a prednisona apresentam possível efeito antioxidante, mas não impedem a necrose e a degeneração Walleriana da medula espinhal de ratos.

 ABSTRACT The aim of the study was investigate the use of the prednisone and meloxicam in treatment of rats underwent to the experimental model of acute spinal cord injury with 2Fr Fogarty catheter, with evaluation of the oxidative stress, neurological test and histopathological analysis of the spinal cord. Ninety rats were separated into six equal groups denominated saline control or SCG, prednisone control or PCG, meloxicam control or MCG, saline and injury or STG, prednisone and injury PTG and meloxicam and injury MTG. Each group was divide into three subgroups according to treatment time in the postoperative period of 24h, 72h and seven days. All the rats underwent laminectomy and in the groups STG, MTG and PTG, after exposure of the spinal cord it was performed a compressive spinal cord injury with a 2Fr Fogarty catheter. The SCG and STG were treated with saline, MSG and MTG, with meloxicam and PSG and PTG with prednisone. All rats were evaluated for oxidative stress, neurological tests and histopathology of the spinal cord. Neurological tests were performed with Basso, Beattie e Bresnahan score (BBB), inclined plane and deep pain 24 hours before and after surgery and repeated every 48 hours until the day of euthanasia. The groups STG, MTG and PTG in the different times were zero point in the BBB scale and three points in the inclined plane and absence of deep pain. MTG and PTG had lower catalase activity and TBARS levels when compared to the STG. In the histopathological analysis it was found Wallerian degeneration and necrosis of gray matter of intensity variation. Meloxicam and prednisone can exhibit antioxidant effect, but the necrosis and Wallerian degeneration were not stop in rats underwent to acute spinal cord injury




3 de abr de 2015

Remoção de pino de Steinmann intra-abdominal por videolaparoscopia em um cão

Laparoscopic removal of a Steinmann pin from the peritoneal cavity in a dog

Ísis dos Santos Dal-Bó, Rafael Stedile, Márcio Poletto Ferreira, Fernanda Silveira Nóbrega, Marcelo Meller Alievi, Luciana Machado da Silva, Elisa Barp Neuwald, Simone Tostes Oliveira, Carlos Afonso de Castro Beck

 Ciência Rural, Santa Maria, v.43, n.2, p.314-317, fev, 2013

RESUMO: Durante a avaliação radiográfica aos 60 dias de pós-operatório de estabilização vertebral em um cão, foi observada a presença de um pino de Steinmann intraabdominal. Foi realizada cirurgia laparoscópica para inspeção cavitária e remoção do objeto. O implante estava envolvido pelo omento, não sendo observados sinais de infecção. O procedimento foi executado em 15 minutos e permitiu mínimo trauma. Os autores não encontraram relatos da migração desse tipo de implante para a cavidade peritoneal em cães com sucessiva remoção videocirúrgica. 

 ABSTRACT An intra-abdominal Steinmann pin was detected during a radiographic assessment of the 60th post- operative day of a vertebral stabilization in a dog. Laparoscopic inspection and retrieval of the foreign body were performed. The implant was surrounded by omentum with no noticeable signs of infection. The procedure was performed within 15 minutes with minimal trauma. To the authors’ knowledge, this is the first report of this kind of implant migration to the peritoneal cavity followed by laparoscopic removal in dogs.

1 de abr de 2015

CRANIOPLASTY FOR REPAIR OF CRANIOSCHISIS ASSOCIATED WITH MENINGOCELE IN A JERSEY CALF

CRANIOPLASTY FOR REPAIR OF CRANIOSCHISIS ASSOCIATED WITH MENINGOCELE IN A JERSEY CALF

 Vet. e Zootec. 2014 set.; 21(3): 392-398.

 José Paes Oliveira Filho, Peres Ramos Badia, Andreza Pimenta Oliveira, Luis Emiliano Cisneros Álvarez, Jorge Luiz Oliveira Costa

 ABSTRACT Cranioschisis with meningocele at the parietal region was diagnosed in a 2-day-old calf. At presentation the animal was standing, attentive and had normal suckling reflex. However, an ovoid, soft, slightly lateral, bladder-like mass was observed extending from the intercornual protuberance to the insertion of the nuchal ligament. Physical examination and radiographs evidenced a deformity of the parietal bone and cranioplasty using a cartilage homograft was performed in an attempt to correct the bone defect. The calf did well postoperatively until day nine. However apathy and seizures were present from day 13 leading to death on day 15

27 de nov de 2014

Doenças neurológicas em cães atendidos no Hospital Veterinário da Universidade Federal de Santa Maria, RS: 1.184 casos (2006-2013)


Link Pesquisa Veterinária Brasileira 34(10):996-1001 , 2014, Chaves R.O., Beckmann D.V., Santos R.P., Aiello G., Andrades A.O., Baumhardt R., Silveira L.B. & Mazzanti A. 
Resumo: Foi realizado um estudo retrospectivo de cães atendidos no Serviço de Neurologia (SN) do Hospital Veterinário Universitário (HVU) da Universidade Federal de Santa Maria (UFSM), de 2006 a 2013, com o objetivo de identificar e caracterizar a idade, a raça, o sexo e as doenças neurológicas e classificá-las de acordo com a região anatômica e o acrônimo DINAMIT-V. Foram avaliadas 1.277 fichas neurológicas de cães e obtidas as informações para inclusão no estudo em 1.184 delas, sendo o diagnóstico confirmado em 525 cães (44,4%) e presuntivo em 659 (55,6%). A raça mais frequente foi Dachshund (28,7%), seguida dos cães sem raça definida. Os locais mais afetados foram medula espinhal entre T3-L3 (40,9%) e tálamo-córtex (17,5%). A maioria dos cães foi diagnosticada com doença degenerativa (49%), sendo a doença do disco intervertebral a mais observada, seguida das doenças inflamatórias/infecciosas (16,6%). Pode se concluir que a maior prevalência das doenças neurológicas de cães envolve a medula espinhal e o tálamo-córtex, sendo as degenerativas as mais frequentes e os dados obtidos podem auxiliar em futuros estudos sobre a frequência e a distribuição das principais doenças neurológicas em cães. 

Neurological diseases in dogs examined at the Veterinary Teaching Hospital of the Federal University of Santa Maria, RS: 1.184 cases (2006-2013).

Abstract:  A retrospective study including dogs with neurological disease was conducted at the  Service of Neurology (SN) of the Veterinary Teaching Hospital, Universidade Federal de  Santa Maria (UFSM) from 2006 to 20133, with the objective to identify and characterize age,  breed, sex and to neurological diseases, and classify them accordingly to the anatomical  region and DINAMIT-V acronym. There were evaluated 1,277 neurological records of dogs  and obtained the information for inclusion in the study in 1,184 of them being the diagnosis  confirmed in 525 (44.4%) and presumptive in 659 dogs (55.6%). The most common breed  was Dachshund (28.7%), followed by mixed bre. ed. The most affected sites were the spinal cord between T3-L3 (40.9%) and thalamus-cortex (17.5%).  Most dogs were diagnosed  with degenerative disorders (49%), being intervertebral disk disease the most observed,  followed by inflammatory/infectious diseases (16.6%).It can be concluded that the higher  prevalence of neurological disorders in dogs involve the spinal cord and thalamus-cortex,  with the most frequent being degenerative and the data obtained may assist future studies  associated with frequency and distribution of the main neurological diseases in dogs.



21 de nov de 2014

Corpectomia lateral parcial associada à pediculectomia no tratamento de condroma extradural em um cão: descrição da técnica

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 66(5): 1323-1328, 2014

Link 
 
MARINHO, P. V. T. ; ZANI, C. C. ; JARK, P. C. ; MINTO, B. W. ; COSTA, M. T.

Partial lateral corpectomy associated with pediculectomy to treat extradural chondroma in a dog: technique description
 
Resumo: Objetivou-se descrever detalhadamente a técnica cirúrgica de corpectomia lateral parcial associada à pediculectomia no tratamento de um condroma extradural in vitro. Uma cadela de 12 anos de idade, raça Cocker Spaniel, foi atendida com ataxia proprioceptiva dos membros pélvicos associada à compressão extradural entre a primeira e a segunda vértebras lombares. Devido a alterações secundárias decorrentes de afecções concomitantes que culminavam em um prognóstico desfavorável, o proprietário optou pela eutanásia do paciente, e o cadáver foi formalmente cedido para realização de descompressão medular experimental. A técnica utilizada foi eficaz na remoção completa da massa extradural, com mínima manipulação da medula espinhal.

Abstract: This study aimed to describe in detail the surgical technique of partial lateral corpectomy (PLC) associated with pediculectomy to treat an in vitro extradural chondroma. A 12-year old female Cocker Spaniel was seen in the hospital with proprioceptive ataxia of hind limbs associated with extradural compression between the 1st and 2nd lumbar vertebrae. The owner opted for euthanasia since the patient?s condition changed due to simultaneous illnesses that culminated in a poor prognosis. The patient?s body was formally ceded to perform experimental spinal decompression. The technique was effective to completely remove the epidural mass with minimal manipulation of the spinal cord.

8 de out de 2014

Total vertebrectomy for stabilisation of chronic spinal lumbar luxation in a paraplegic dog without nociception

 

Journal of Small Animal Practice,Volume 55, Issue 10, Pages 485–541, October 2014

P. V. Tertuliano Marinho,C. C. Zani, F. De Biasi and M. V. Bahr Arias

 http://onlinelibrary.wiley.com/doi/10.1111/jsap.12246/abstract

         An adult male crossbred dog was referred with a history of a road traffic accident that took place 1 month earlier. Neurological examination revealed paraplegia with absent nociception in the pelvic limbs. On epaxial palpation, significant curvature of the anatomical axis of the spine between the third and fourth lumbar vertebrae was observed, with the presence of a bone end almost piercing the dog's skin. Survey radiographs of the lumbar spine revealed severe dislocation between L3 and L4 vertebrae. During surgery, the spinal cord was not visible between the dislocated segments. Because of difficulties in reducing the lumbar luxation during surgery, vertebrectomy and vertebral shortening were performed. After alignment between vertebrae L3 and L5, eight cortical orthopaedic screws and bone cement were used for fixation. After 30 days, the dog started to use a wheelchair and was considered by its owner to have a good quality of life with no evidence of pain. To the authors’ knowledge, this is the first case of severe luxation treated by total vertebrectomy and spine shortening in a dog. This surgery can be considered as an option in the management of severe spine luxation when the spinal cord is physically transected.

3 de out de 2014

Abiotrofia cerebelar em um canino American Staffordshire Terrier adulto no Brasil

 Cerebellar Abiotrophy in an American Staffordshire Terrier Adult Dog in Brazil

http://www.ufrgs.br/actavet/42-suple-1/CR_52.pdf

Acta Scientiae Veterinariae, 2014. 42(Suppl 1): 52.

Cristine Mari, Daniele Mariath Bassuino, Angelica Terezinha Barth Wouters, Marcele Bettim Bandinelli, David Driemeier & Saulo Petinatti Pavarini

Cerebellar abiotrophy is a spontaneous, progressive degenerative disease of the cerebellum in which Purkinje cell loss and functional disorders occur secondary to an intrinsic metabolic defect. Clinically, all animals with cerebellar  abiotrophy are normal at birth, and neurological signs become evident during development. This work aimed to report  and describe a case of cerebellar cortical abiotrophy in an adult American Staffordshire Terrier in Brazil, highlighting the  pathologic findings of the cerebellar lesions. A 10-year-old female American Staffordshire Terrier presented with a 3-year history of progressive neurological  changes.  These changes began with mild ataxia of the hind limbs that involved the forelimbs after 2 years. In the recent  months prior to presentation, the patient spent most of her time lying down with a head tilt. When she stood with her head  raised, she exhibited abasia and required a broad base of support. When she attempted to walk, she quickly fell and rolled  over if not supported. She could not eat on her own because of intense intention tremors. Because of the severity of her  condition, the decision was made to euthanize the animal. Necropsy examination revealed no signifi cant findings. Various organ specimens were collected, fi xed in 10% formalin, and processed for routine histology. The tissue sections were  stained with hematoxylin and eosin. Cerebellar specimens were subjected to immunohistochemistry (IHC). Two cerebellar specimens from two normal 8- to 9-year-old American Staffordshire Terriers were used as positive controls for IHC andand  comparative evaluation of the lesions. Histologically, the main changes were observed in the cerebellum and were characterized by necrosis, degeneration, and marked segmental loss of Purkinje cells; moderate reduction in the granular cells of  the cerebellar cortex; and thinning of the molecular layer. Cerebellar IHC in the affected canine showed a slight reduction
in immunoreactivity for neurofi laments in both the molecular layer and white matter as well as a marked increase in immunostaining for glial fi brillary acidic protein, indicating astrogliosis, in the molecular layer, granular layer, and white matter.  The diagnosis of cerebellar abiotrophy in this canine patient was based on clinical, pathologic, and immunohistochemical fi ndings. The framework cerebellar syndrome in an adult dog, slowly progressive, as in this case (10 years old with a 3-year clinical progression) is compatible with abiotrophy in the American Staffordshire Terrier. The main gross  lesions observed in the cerebellum of canines with abiotrophy are projected to decline; however, these changes can be subtle,  as in this case. Histopathology revealed a primary loss of Purkinje cells and depletion of the molecular and granular layers.  These characteristics have been identifi ed as hereditary in American Staffordshire Terriers and other breeds. The clinical  signs observed in this patient, namely ataxia, intention tremors, and abasia, refl ect the loss of function of the inhibitory  neurons of the cerebellar cortex. The fact that cerebellar abiotrophy is relatively common in purebred dogs and the great  variety in the early clinical signs and progression suggests different genetic etiologies in different breeds. An association  with breed is evidenced by the fact that the clinical manifestations of cerebellar abiotrophy in American Staffordshire Terriers start late and have been shown to be hereditary. This paper reports the occurrence of cerebellar cortex  abiotrophy as  a cause of neurological disease in an American Staffordshire Terrier in Brazil.

29 de set de 2014

Hipoplasia medular segmentar múltipla em um felino doméstico

http://www.ufrgs.br/actavet/42-suple-1/CR_41.pdf
 Acta Scientiae Veterinariae, 2014. 42(Suppl 1): 41.

Vinicius Gonzalez Peres Albernaz, Andressa Thais Roncoski, Gustavo Dittrich, Liv Cristina Miara & Jorge Luiz Costa Castro

Multiple Segmental Spinal Cord Hypoplasia in a Cat

The nervous system is one of the most affected by congenital malformations. These can occur during neural  tube formation or failed neurogenesis. Segmental spinal cord hypoplasia  commonly involves two or three spinal segments  in the thoracolumbar region. It is characterized by incomplete formation of the spinal cord and may also be followed by  spine column malformations. Clinical signs usually include functional impairment of the hindlimbs. Diagnosis is based  on history, clinical signs, age, radiographs and is confi rmed with necropsy and histopathological fi ndings.  There is no  treatment for this condition and the animals present low life quality. This paper aims to report the clinical, radiographic  and histopathological aspects of multiple segmental spinal cord hypoplasia in a domestic cat.  A 52-days-old, female, Persian breed, domestic cat weighing 0.55 kg was treated presenting a history of pelvic limb  paraplegia associated with urinary and fecal incontinence since birth. On clinical examination there were fl accid paraplegia  of hind limbs associated with absence of proprioception, anal refl ex and tone and postural defi cits. Also, all spinal reflexes  of pelvic limbs and deep and superfi cial pain were absent. There was no clinical history of muscular tremors, nystagmus,  seizures or other central nervous system signs. The other animals of the litter showed no apparent changes. Radiographic examination of the thoracolumbar and lumbosacral region showed enlargement of the spinal cord canal extending from the caudal portion of L1 to L7 and fl attening of the dorsal and ventral blades. It was observed that the height of the L5 spinal canal, the larger dilatation site, was about 300% higher than the cranial portion of L1, considered the last normal segment. Due to low life quality, the animal was euthanized and samples were collected. Histopathological examination showed neuronal loss in the gray matter, thickening of the dura mater and loss of defi nition of gray and white matter, confirming the diagnosis of spinal segmental hypoplasia in multiple regions of the spinal cord



26 de set de 2014

Síndrome de Haw em Gatos

http://www.ufrgs.br/actavet/42-suple-1/CR_45.pdf
 Acta Scientiae Veterinariae, 2014. 42(Suppl 1): 45

Luis Felipe Dutra Corrêa,  Sérgio Santalucia,  Marília Teresa de Oliveira,  Fernando Wiecheteck de Souza, Virginea Heinze Pohl,  João Pedro Scusssel Feranti,  & Maurício Veloso Brun, 

 Haw’s syndrome is an uncommon but underdiagnosed disease that affects cats. It occurs due to changes in the innervation of the third eyelid causing protrusion. These changes may occur due to some change in sympathetic innervation efferent to the eye and its annexes The diagnosis is based on the instillation of sympathomimetic agents. The palliative treatment is based on the instillation of sympathomimetic agents only if the protrusion is preventing eyesight. The aim of this study is to report the clinical management of three cats with this syndrome, emphasizing its clinical, diagnostic and treatment demonstration. Three cats were referred to the Department of Ophthalmology Veterinary of the Catholic University of Rio Grande do Sul (PUCRS), two with undefi ned breeds (male and female) and a Siamese (male), aged between 2 and 4 years, with bilateral protrusion of the third eyelid. The owners reported that the animals ate well, were active and did not observe any other problems concomitantly, with the exception of diarrhea In one of the animals a week ago, but that had passed. The animals underwent a complete ophthalmologic examination where they were evaluated since the symmetry orbits until intraocular pressure, Schirmer tear test, fl uorescein test and lissamine green, without any obvious change, with values within the normal range for the species, except for the bilateral protrusion of the third eyelid was the only clinical sign present. In the fundoscopic exam no apparent changes were observed, with the optic nerve head and retinal vasculature normal for the species. All patients received instillation of 10% phenylephrine in the left eye, with total regression of the third  eyelid to its anatomical position. As it was an isolated problem, without visual or systemic  repercussions, no medication was prescribed, although the animals kept coming for revisions weekly for 60 days. After 47 days, on average, the third eyelid returned to its anatomical position.

22 de set de 2014

Anestesia epidural na cirurgia descompressiva lombossacral de cães

http://www.scielo.br/pdf/abmvz/v66n3/0102-0935-abmvz-66-03-00787.pdf
E.A. Tudury 1 , T.H.T. Fernandes 2 *, M.L. Figueiredo 2 , B.M. Araújo2 , M.A. Bonelli 2 , A.C. Silva 2 , C.R.O. Santos 3
1Universidade Federal Rural de Pernambuco -UFRPE - Recife, PE
2Alunos de pós-graduação - Universidade Federal Rural de Pernambuco - UFRPE - Recife, PE
3Aluna de graduação - Universidade Federal Rural de Pernambuco -UFRPE - Recife, PE

 Arq. Bras. Med. Vet. Zootec. vol.66 no.3 Belo Horizonte June 2014

Objetivou-se avaliar viabilidade, eficácia, vantagens e desvantagens da anestesia epidural lombossacral, junto à anestesia geral inalatória, em cirurgias de descompressão da cauda equina, tendo em vista que essas cirurgias são procedimentos longos e dolorosos. Para isso, foram utilizados 11 cães adultos com sinais clínicos de síndrome da cauda equina, que foram submetidos à anestesia geral inalatória e deixados no estágio anestésico mais superficial. Depois, realizou-se a anestesia epidural em seis dos 11 pacientes, por punção espinhal em L7-S1, com bupivacaína a 0,5%. Os parâmetros fisiológicos (cardíacos, vasculares, respiratórios, temperatura corporal e glicemia) foram aferidos antes da medicação pré-anestésica, 10 minutos após esta, 30 minutos depois da epidural, depois da laminectomia, assim como após 60 minutos e 90 minutos da epidural, tanto no grupo com epidural como naquele sem esta (controle). Os animais que possuíam bloqueio epidural apresentaram redução significativa no consumo de anestésico inalatório e no tempo de extubação, não apresentando déficits neurológicos causados pela anestesia epidural, quando comparados com o grupo-controle. Conclui-se que a técnica de anestesia epidural é eficiente e vantajosa na realização de cirurgias descompressivas lombossacrais, pois proporciona menor risco anestésico para o animal.
Palavras-Chave: cauda equina; bloqueio anestésico; analgesia


The objective of this study was to evaluate the feasibility, effectiveness, advantages and disadvantages of lumbosacral epidural anesthesia with inhalational anesthesia in surgical decompression of the cauda equina, since this surgery has a lengthy and painful recovery from anesthesia. For this, 11 adult dogs which showed clinical signs of cauda equina syndrome were used. After the epidural, anesthesia in six of 11 patients, spinal tap in L7-S1, with bupivacaine 0.5% anesthetic was used. Physiological parameters (heart, vascular, respiratory and body temperature) were measured before, 10 minutes after, and 30 minutes after the epidural, after the laminectomia and 60 minutes and 90 minutes after the epidural, both in the epidural group and the control group. Animals that had ep showed a significant reduction in consumption of inhaled anesthetic and time of extubation. There were no neurological deficits caused by epidural anesthesia compared with the group without epidural anesthesia. It was concluded that the epidural anesthesia technique is effective in lumbosacral decompression surgeries, leading to a lower risk for the anesthetized animal.
Key words: cauda equina; anesthesia; analgesia

20 de set de 2014

Mielografia lombar no diagnóstico de extrusão do disco intervertebral toracolombar em cães: estudo prospectivo

http://www.uel.br/revistas/uel/index.php/semagrarias/article/view/15110/pdf_380
Semina: Ciências Agrárias, Londrina, v. 35, n. 4, p. 1871-1880, jul./ago. 2014

Lumbar myelography in the diagnosis of thoracolumbar  intervertebral disk extrusion in dogs: prospective study

Paulo Vinicius Tertuliano Marinho, Bruno Watanabe Minto, Carolina Camargo Zani, Érica Siqueira de Souza, Nathália Helena Pereira da Silva Dal Pietro, João Augusto Leonel de Souza, Júlio Carlos Canola, Andrigo Barboza De Nardi

Resumo:A extrusão do disco toracolombar é a causa mais comum de compressão extradural da medula espinhal em cães. A mielografia é uma das técnicas mais comumente realizadas para o diagnóstico desta afecção. Objetivou-se avaliar a aplicabilidade e efetividade da técnica de mielografia lombar no diagnóstico de extrusão do disco intervertebral toracolombar em cães, bem como suas principais complicações. Foram utilizados 20 animais que ao exame neurológico apresentaram localização da lesão na região toracolombar e que tiveram indicação de mielografia como método diagnóstico complementar e confirmação do diagnóstico de extrusão do disco no trans-operatório. Avaliou-se a precisão do exame na localização e lateralização da lesão, e as complicações associadas ao procedimento. A mielografia lombar teve acurácia de 95% e 60% para a localização e a lateralização da lesão respectivamente, com complicações mínimas.
Abstract: Thoracolumbar disk extrusion is the most common cause of extradural compression of the spinal cord  in dogs. Myelography is one of the most commonly performed techniques for the diagnosis of this  affection. This study aimed to evaluate the applicability and effectiveness of lumbar myelography in  the diagnosis of thoracolumbar intervertebral disk extrusion in dogs, as well as its major  complications. Twenty dogs were used in this study. Animals were included when neurological examination suggested thoracolumbar spine lesion, myelography was used as a complementary diagnostic method, and diagnosis of disk extrusion was surgically confirmed. The accuracy of the exam to predict location and lateralization of extruded disk material were evaluated, as well as complications associated to the  procedure. Lumbar myelography exhibited 95% and 60% accuracy for location and lateralization of the lesion, respectively, with minimal complications

21 de ago de 2014

Sensory-Motor Neuropathy Due to Vincristine Treatment in a Dog

link

Acta Scientiae Veterinariae, 2014. 42(Suppl 1): 59.

Autores: Bernardo De Caro Martins, Guilherme De Caro Martins, Rodrigo dos Santos Horta, Bruno Benetti Junta Torres, Stephanie Elise Muniz Tavares Branco & Gleidice Eunice Lavalle
From: Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária (EV), Universidade Federal de Minas Gerais, Brazil

Abstract:
Background: Peripheral neuropathies secondary to chemotherapy drugs, especially when it comes to the use of vincristine, are common in humans, but rare in dogs. Neurologic manifestation depends on the kind of axonal fi bers involved. When motor fi bers are affected, weakness and ataxia are  observed. Sensory fibers involvement, which can lead to hyperesthesia, hypoesthesia or paresthesia was reported experimentally in rats, and is common in humans but were never reported in dogs. Thus, this report aims at describing a mixed neuropathy, with sensory and motor involvement, in a dog after vincristine treatment. 
Case: A one year old mixed breed dog, rescued from the street, was presented with multiple nodular and ulcerated lesions, disseminated on the head, gums, flank and limbs, with progressive worsening in the last two months. Cytology of two subcutaneous and one gum nodule revealed an intense concentration of neutrophils and round cells with abnormally clumped chromatin patterns, prominent nucleoli and multiple cytoplasmic vacuoles, compatible with TVT. Treatment was initiated with a weekly administration of vincristine (0,75 mg/m2) combined with anti-emetic (maropitant) and H1 receptor inhibitor (ranitidine). Fast remission of the cutaneous lesions occurred. However, after the second chemo session, generalized hyperesthesia, mild ataxia, intermittent collapse and vomiting were observed. Suspicion of a mixed (sensory-motor) neuropathy induced by vincristine emerged, and vincristine was ceased. No other chemotherapy treatment was instituted due to negative cytological results of the remaining lesions. Treatment with gabapentin (10 mg/kg, twice a day, orally) was initiated so that neuropathic pain was suppressed. After one week, the patient no longer demonstrated pain, walked normally and lesion remission was complete. The animal has been monitored for eight months and is currently stable, with no lesions, pain or any changes that compromises its quality of life.
Discussion: Although vincristine is considered to be the most effective and least toxic chemotherapy drug used for treating this neoplasia, some side effects may occur, such as vomiting, anorexia, depression and myelosuppression. In addition, some animals may suddenly develop peripheral neuropathy, with the involvement of motor fi bers, which results in weakness and ataxia. Involvement of sensory fi bers, in combination or not with motor fi bers, as vincristine treatment side effect, is commonly notice in humans but never observed in dogs, wherein allodynia and paresthesia can be manifested. In this case, the diagnosis of peripheral mix neuropathy, with motor and sensory fi bers involvement, was made by identifying clinical signs after vincristine treatment initiation and immediate remission after discontinuation. This is often enough for a defi nitive diagnosis, as there are no additional tests that identify, in an early matter, neuropathy caused by chemotherapy. Despite there is no specifi c treatment, gabapentin can be used to control neuropathic pain as it increases GABA and serotonin concentration, reducing nociceptive ascending impulses. After chemotherapy discontinuation and gabapentin treatment, there was remission of neurological signs. Vincristine-induced neuropathies constitute a persistent limitation of animal’s quality of life, especially when there is irreversible damage. It is important to identify early motor and sensory neurological signs so that chemotherapy can be immediately suspended. Therefore, the clinician must be able to identify the best moment to discontinue chemotherapy at the expense of patient’s clinical oncology state improvement, while prioritizing the animal’s quality of life.

8 de jul de 2014

Doença do disco intervertebral Hansen tipo II em cães: fisiopatologia, abordagem clínico-cirúrgica e controvérsias

http://www.uel.br/revistas/uel/index.php/semagrarias/article/view/14819/pdf_338

 Semina: Ciências Agrárias, Londrina, v. 35, n. 3, p. 1395-1414, maio/jun. 2014

Autores: Paulo Vinicius Tertuliano Marinho; Mônica Vicky Bahr Arias, Carolina Camargo Zani, Bruno Watanabe Minto

Resumo: A protrusão do disco intervertebral pode provocar compressão progressiva crônica da medula espinhal  e os sinais neurológicos associados variam de acordo com a localização anatômica, duração e força  dinâmica da compressão. A doença do disco tipo II não é totalmente compreendida, havendo muitas  controvérsias sobre seu significado clínico e melhor forma de tratamento. O aspecto mais importante  do tratamento conservador refere-se ao repouso associado à fisioterapia e exercícios leves, além de  uso de corticoesteróides para diminuir o edema vasogênico. A descompressão medular por meio de cirurgia para remoção de material do disco do interior do canal medular é o tratamento cirúrgico de eleição na doença do disco tipo I, mas apresenta limitações quanto à técnica e ao resultado na doença do  disco do tipo II. O objetivo deste trabalho é revisar a fisiopatologia e o tratamento da doença do disco  intervertebral crônica e discutir as controvérsias existentes no tratamento médico bem como o uso de  técnicas cirúrgicas tradicionais e novas técnicas.

Hansen type II disc disease in dogs: pathophysiology, clinical - surgical approach and controversies

Abstract:  Protrusion of the intervertebral disc can cause chronic progressive compression of the spinal cord, and the neurological associated signs vary according to anatomical location, duration and dynamic force of compression. The type II disc disease is not fully understood, and there are many controversies about is clinical significance and best form of treatment. The most important aspect of conservative treatment is rest and physiotherapy associated with mild exercise, and use of corticosteroids to reduce vasogenic edema. The spinal decompression by surgery for removal of disc material from within the medullary canal is the surgical treatment of choice in type I disc disease, but has technical limitations in the type II disc disease. The purpose of this paper is to review the pathophysiology and treatment of chronic intervertebral disc disease and discuss the controversies in medical treatment and the use of  some traditional and new surgical techniques.

5 de mai de 2014

A presença das síndromes cerebelares

Revista Cães e Gatos - Ano 30, número 174, 2014
Início da reportagem - página 26
Link


21 de mar de 2014

Perspectivas da aplicação das conotoxinas bloqueadoras de canais para cálcio dependentes de voltagem no trauma medular


http://www.scielo.br/pdf/cr/v44n3/a7514cr2012-0539.pdf 
Autores: Karen Maciel de OliveiraI, Mário Sérgio Lima LavorI  Fabíola Bono Fukushima, Fátima Caetano Caldeira,  Eliane Gonçalves Melo
Ciência Rural, Santa Maria, v.44, n.3, p.501-509, mar, 2014
Resumo: O bloqueio dos canais para cálcio dependentes  de voltagem é uma estratégia importante no tratamento do trauma medular, pois previne o influxo exacerbado do cálcio que participa ativamente em processos neurodegenerativos agudos, resultando em neuroproteção com melhora das funções neurológicas. Dentre esses bloqueadores, as toxinas de caramujos marinhos são peptídeos com adequada estabilidade estrutural, estudadas pelas ações específicas em canais iônicos e receptores que interferem diretamente na liberação de  neurotransmissores e na neuromodulação dos neurônios motores e sensitivos da medula espinal. Elas já são utilizadas no tratamento de desordens neurológicas e mostram-se promissoras no desenvolvimento de novas terapias para o trauma medular. Portanto, objetivou-se discorrer sobre a fisiopatologia do trauma medular e a possível utilização terapêutica das toxinas de caramujo marinho, atuantes nos principais canais para cálcio dependentes de voltagem.
Perspectives for the application of voltage-dependent calcium channels blockers conotoxin in spinal cord injury
ABSTRACT: Blocking voltage dependent calcium channels is an  important strategy in acute spinal trauma treatment, because it  prevents the exacerbated calcium infl ux which participates actively  in acute neurodegenerative processes, resulting in neuroprotection  with improvement of neurological and electrophysiological  functions. The cone snail toxins are peptides with adequate  structural stability, which have been studied by specifi c actions on  ion channels and receptors that directly interfering in the release of neurotransmitters and neuromodulation of sensory and motor neurons of the spinal cord. They are already used in the treatment  of neurological disorders and appear to be promising in the  development of new therapies for spinal trauma. Therefore, it was  aimed to discuss the pathophysiology of spinal cord trauma, and possible therapeutic use of marine snail toxins that acts in voltage-dependent calcium channels.




24 de fev de 2014

Tumor venéreo transmissível canino com metástase encefálica

Semina Ciências Agrárias: v34, n.6, supl 2, 2013
Autores: Ciciane Pereira Marten Fernandes, Luiz Fernando Jantzen Gaspar, Ana Raquel Mano Meinerz, Fabiane Borelli Grecco, Márcia Oliveira Nobre, Marlete Brum Cleff

Resumo: Relata-se o primeiro caso no Brasil de tumor venéreo transmissível (TVT) vaginal com metástase para o sistema nervoso central (SNC), além do envolvimento do tecido cutâneo, ocular e pulmonar e descreve a resistência do TVT ao tratamento com vincristina. O TVT é uma neoplasia contagiosa ocorrendo, principalmente, em locais em que não ocorre um controle populacional de cães, e atualmente tem sido demonstrada resistência destas células tumorais ao tratamento convencional com vincristina. Foi atendida uma fêmea canina, sem raça definida, com cerca de cinco anos de idade, pesando 9,2kg, com histórico de sangramento vaginal há mais de seis meses. Após diagnóstico citológico de TVT foi recomendado tratamento com quimioterápico. Houve resistência a quimioterapia com sulfato de vincristina, preconizando a utilização de quimioterápico doxorrubicina. Suspeita-se que o desenvolvimento do tumor no sistema nervoso central possivelmente tenha ocorrido devido à doxorrubicina não ter capacidade de atravessar a barreira hematoencefálica, aliado à resistência à vincristina.

Abstract: The first case in Brazil of vaginal TVT with metastasis for the central nervous system is reported, as well as the presence of cutaneous, eye and lung metastases and describes the resistance of the TVT to treatment with vincristine. The TVT is a contagious neoplasm that occurs mainly in places where there is no dog population control, and currently, resistance of these tumor cells to conventional treatment with vincristine has been demonstrated. A mongrel female dog of about five years old, weighing 9.2 kg, with a history of vaginal bleeding for more than six months was attended. After cytological diagnosis, treatment with chemotherapy was recommended. There was resistance to chemotherapy treatment with vincristine sulfate, advocating the use of doxorubicin. It is suspected that tumor development in the central nervous system possibly occurred because the doxorubicin was not capable of crossing the hematoencephalic barrier, along with resistance to vincristine.

16 de jan de 2014

Potencial evocado auditivo para diagnóstico de surdez em gato com síndrome vestibular periférica

Autores: M.I.P. Palumbo, P.C. Jark, L.H.A. Machado, V.M.V. Machado, L.A.L. Resende,  A.S. Borges

Arq. Bras. Med. Vet. Zootec., v.65, n.6, p.1681-1684, 2013


RESUMO: Potencial evocado auditivo é um método eletrodiagnóstico que permite avaliação funcional das vias  auditivas desde a orelha média até o tronco encefálico. O uso desse teste em medicina veterinária é pouco  difundido no Brasil. O presente artigo relata o uso do potencial evocado auditivo para detecção de 
deficiência auditiva unilateral em um gato com síndrome vestibular periférica secundária a otite média. 
 
ABSTRACT: The brainstem auditory evoked potential is an electrodiagnostic test that allows a functional assessment  of the auditory pathways from the middle ear to the brainstem. This test, in veterinary medicine, is not  commonly used in Brazil. This paper reports the use of auditory evoked potential for deafness detection in  a cat with unilateral peripheral vestibular syndrome secondary to otitis media

 Especialista em audição de animais visita a FMVZ
O norte-americano George Strain ministrou palestras e disciplina de pós-graduação

7 de jan de 2014

UTILIZAÇÃO DO ÍNDICE DE NORMALIDADE DA DISTÂNCIA ATLANTOAXIAL DORSAL EM CÃES COM SUBLUXAÇÃO ATLANTOAXIAL

XIII JORNADA DE ENSINO, PESQUISA E EXTENSÃO – JEPEX 2013 – UFRPE: Recif

Eduardo Alberto Tudury,  Amanda Camilo Silva

Link

ÍNDICE DE NORMALIDADE DA DISTÂNCIA ATLANTOAXIAL DORSAL EM CÃES DE RAÇAS TOY

XIII JORNADA DE ENSINO, PESQUISA E EXTENSÃO – JEPEX 2013 – UFRPE: Recife

Eduardo Alberto Tudury,  Amanda Camilo Silva,  Bruno Martins Araújo,  Maria Albeline Silva de Lacerda,  Marcela Maria Almeida Amorim, Jacinta Eufrásia Brito Leite



Link



26 de nov de 2013

Axis Fracture Repair with Locking Plate in Dog

Acta Scientiae Veterinariae, 2013. 41(Suppl 1): 28.

http://www.ufrgs.br/actavet/41-suple-1/CR_28.pdf

Autores: Paulo Vinícius Tertuliano Marinho, , Rodrigo de Souza Mendes,  Juliana Molina Martins, Renato Otaviano do Rego,  Erica Emerenciano Albuquerque,  & Carolina Camargo Zani


Background: Cervical fractures in dogs occur most commonly in the cranial region, mostly requiring surgery. Various types of implants are being used while fixation using plate is poorly described in the literature. The plate and screw types are a limiting factor since they can lead to loss of stability due to loosening of the screws. The use of locking plates has been advocated, which does not allow movement between the screw-plate-bone, providing extreme stability and rigidity to the system. This study describes the use of locking bone plate to stabilize axis fracture in a dog and the results obtained with this technique. 
Case: A 9-month-old male Poodle presented due to a history of trauma to the cervical spine caused by a fall of an object. Upon physical examination, the patient was alert and physiological parameters within the normal reference limits. However, neurological examination showed tetraplegia, hyperreflexia, preserved nociception and much cervical pain. There were no changes in the cranial nerves test. Cranial cervical lesion was initially suspected and the patient was rigidly fixed on a flat surface. The radiographic examination showed a fracture of the second cervical vertebra (axis) with anatomical axis deviation, and the patient was referred for surgery. After anesthesia, the dog was positioned dorsal decubitus and rigidly fixed on the operating table with the thoracic limbs pulled caudally. The surgical approach of the cranial cervical spine started through the ventral access until complete visualization of the fracture line and the caudal portion of the axis body. After perfect apposition and alignment of the bone fragments, rigid stabilization was performed using locking plate and screws. The patient had a favorable neurological recovery, and five days after the surgery, no change was observed in locomotion and postural reactions, besides the absence of neck pain. 
Discussion: The implant used in this study was small and displayed a good fi t along the body axis. The locked system allowed the bolt head to lock in the hole of the plate, forming a bone-screw-plate unit that prevents its failure. In our case, the tip of the caudal screws protruded approximately two millimeters within the spinal canal, without any apparent effect on the outcome. In a previous study, in which plates were used for ventral fixation and stabilization of the atlantoaxial joint, the screws also protruded into the vertebral canal without causing any problems, presumably because the cervical vertebral canal is wider than the diameter of the spinal cord at this location. Failure rate of up to 44% has been reported for all the processes of atlantoaxial ventral fixation if the surgery is deemed successful when resolution of neurological signs occurs, and there is no need for further surgery. According to this, the present case can be considered successful
taking into account the clinical outcome after surgery, the rapid reduction of pain, return to ambulation and the absence of neurological deficits. We conclude that the locking plate was a viable alternative to other fixation techniques for fractures involving the second cervical vertebra in small animals since it allowed relative stability of the fracture and an excellent neurological recovery of the patient.



31 de out de 2013

AVALIAÇÕES PRÉNATAL ULTRASSONOGRÁFICA E RADIOGRÁFICA NO DIAGNÓSTICO DE ANENCEFALIA EM CÃO - RELATO DE CASO


da Veiga C.C.P., de Souza B.G. &Vieira S.L

Revista Brasileira de Medicina Veterinária, 35(2):101-104, 2013


A anencefalia é uma malformação da cabeça e está entre as malformações que envolvem defeitos no tubo neural do embrião. Em humanos os defeitos do tubo neural são malformações comuns, entretanto em medicina veterinária estas malformações são consideradas raras. O exame ultrassonográfico é muito utilizado na rotina clínica veterinária no que diz respeito à gestação. Anomalias do concepto detectadas pelo exame ultrassonográfico pré-natal tem sido descritas em cães. O objetivo deste trabalho é descrever o resultado ultrassonográfico realizado na avaliação pré-natal e os achados radiográficos de um feto, onde foi possível diagnosticar anencefalia. Conclui-se com o presente estudo que a ultrassonografia torna-se útil na avaliação gestacional e quando associada com a radiográfica permitiram identificar anencefalia. Neste caso, demonstrou-se a enfermidade debilitante em um cão e assinala a importância de estudos com malformações embrionárias nesta espécie para que se possa determinar a real importância destas malformações e se há fatores desencadeantes com o intuito de minimizar problemas financeiros e emocionais com a perda de conceptos.